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Xi Mo, PhD

 

Title

Primary Investigator, Institute for Pediatric Translational Medicine; Shanghai Children’s Medical Center; 

Bio

Dr. Xi Mo graduated from School of Life Sciences from University of Science and Technology of China in 2003 as Bachelor or Science.  During her undergraduate research, she was focus on the crystal structure and function of snake venoms. Dr. Mo started her Ph.D. study in 2004 at University of Texas Health Science Center at Houston, and after she finished her Ph.D. in 2009, she continued for a year of postdoctoral research.  During the last 6 years in US, Dr. Mo was focus on the research of structure and function of platelet receptor glycoprotein Ib-IX-V complex, which is critical for both thrombosis and haemostasis.  In the past 5 years, Dr. Mo has published 6 SCI papers (total impact factor 38) as first author; in addition, she has also published 4 conference abstracts, given several oral and poster presentations in international conferences, and been awarded many research scholarships and awards

 

Education and Training

08/2009~08/2010  Postdoctoral fellow (Advisor: Dr. Renhao Li)

Center for Membrane Biology

Department of Biochemistry and Molecular Biology

Graduate School of Biomedical Sciences

UT Health Science Center at Houston (UTHSC-H)

Projects: Organization and function of platelet glycoprotein Ib-IX complex

Regulation of ectodomain shedding of L-selectin

08/2004~07/2009  Ph.D. (Advisor: Dr. Renhao Li)

Center for Membrane Biology

Department of Biochemistry and Molecular Biology

Graduate School of Biomedical Sciences

UT Health Science Center at Houston (UTHSC-H)

Projects: Organization and function of platelet glycoprotein Ib-IX complex

09/1999~07/2003  B.Sc.

Department of Biochemistry and Molecular Biology

School of Life Sciences

University of Science and Technology of China (USTC)

Dissertation: Purification and crystallization of cardiotoxin and phospholipase A2 from Naja atra venom; partial characterization of L-amino acid oxidase from the snake venom of Aglistrodon halys Pallas

 

Awards and Honors

2009           Young Investigator Award of International Society of Thrombosis and Haemostasis

2009           UT Medical School Student Travel Award

2009           UTHSC Student Travel Award

2009           Gulf Coast Consortia Membrane Biology Symposium

                   Poster Presentation—3rd prize

2009           Outstanding Chinese student in Big Houston Area

2008           UT Department of Biochemistry and Molecular Biology Retreat

                   Student Poster Presentation—1st prize

2008           UTHSC Presidents’ Research Scholarship

2007          Travel Award of Annual Meeting of American Society of Hematology

2007           UTHSC Student Travel Award

2007           UT Medical School Dean’s Research Award

2007           UT Department of Biochemistry and Molecular Biology Retreat

                   Student Oral Presentation—1st prize

2007           Harry S. and Isabel C. Cameron Foundation Fellowship

2006           UTHSC Student Travel Award

2005           UTHSC Student Travel Award

1999           USTC Outstanding Student Award

 

Peer Reviewed Publications

1. Mo, X., Nguyen,  McEwan, P., Zheng, X., López, J.A., Emsley, J., and Li, R. (2009) Binding of platelet glycoprotein Ib through the convex surface of leucine-rich repeats in the extracellular domain of glycoprotein IX. J. Thromb. Haemost. (In Press)

2. Mileykovskaya, E., Ryan, A.C., Mo, X., Lin, C.C., Khalaf, K.I., Dowhan, W., and Garrett, T.A. (2009) Phosphatidic acid and N-acyl phosphatidylethanolamine form membrane domains in Escherichia coli mutant lacking cardiolipin and phosphatidylglycerol. J. Biol. Chem. 284(5):2990-3000

3. Mo, X., Luo, S.-Z., López, J.A., and Li, R. (2008) Juxtamembrane basic residues in glycoprotein Ib cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex. FEBS Lett. 582:3270-3274

4. Mo X, Luo, S.-Z., Munday, A.M., Sun, W., Berndt, M.C., López, J.A., Dong, J.-F., and Li, R. (2008) The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence the receptor binding to von Willebrand factor. J. Thromb. Haemost. 6(10):1789-95

5. Luo, S.-Z., Mo, X., López, J.A., and Li, R. (2007) Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex. J. Thromb. Haemost. 5(12):2494-502

6. Luo, S.-Z.,* Mo, X.,* Afshar-Kharghan, V., Srinivasan, S., López, J.A., and Li, R. (2007) Glycoprotein Ib forms disulfides with two glycoprotein Ib subunits in the resting platelets. Blood 109(2):603-9 (* Equal contribution)

7. Mo, X., Lu, N., Padilla, A., López, J.A., and Li, R.  (2006) The transmembrane domain of glycoprotein Ib is critical to efficient expression of glycoprotein Ib-IX complex in the plasma membrane. J. Biol. Chem. 281(32):23050-9

 

Published Abstracts:

1. Mo X, Luo, S.-Z., Peng, Y., Munday, A.M., Sun, C., Berndt, M.C.,López, J.A., Dong, J.-F., and Li, R. (2007) Removing the covalent links between GP Ib and GP Ib hampers binding of von Willebrand Factor to GP Ib-IX Complex in CHO cells. Blood 110(11):1064a.

2. Mo, X., López, J.A., and Li, R. (2006) The Cytoplasmic Domain of Glycoprotein Ib is Critical to Surface Trafficking of Glycoprotein Ib-IX Complex. Blood 108(11):440a.

3. Mileykovskaya, E., Mo, X., Lin, C.-C., Das, S., Loewen, C. Jr., Levine, T., and Dowhan, W. (2006) Role of membrane lipids in bacterial cell division: study of an E. coli mutant lacking phosphatidylglycerol and cardiolipin. Book of Abstracts of EMBO Workshop in “Cell cycle and Cytoskeletal Elements in Bacteria”:97.

4. Mo, X., Lu, N., Luo, S.-Z., Padilla, A., López, J.A., and Li, R.  (2005) The interaction between transmembrane domains of glycoprotein Ib and Ib is critical to efficient expression and assembly of the glycoprotein Ib-IX complex. Blood 106(11):997a

 

 

Papers under review and preparation:

1. Mo, X., Nguyen, N.X., Mu, F.t., Yang, W., Luo, S.-Z., Fan, H., Andrews, R.K., Berndt, M.C., and Li, R. (2010) Trans-membrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Iba. (Under revision of J. Biol. Chem.)

2. Mo, X., López, J.A., and Li, R. (2010) The transmembrane domain of glycoprotein V is critical to its association with glycoprotein Ib-IX complex and efficient expression in the plasma membrane. Manuscript in preparation

 

Presentation

1. Oral Presentation& Poster PresentationInternational Society of Thrombosis and Hemostasis2009

2. Oral Presentation& Poster PresentationAmerican Society of Hematology2007

3. Oral Presentation& Poster PresentationAmerican Society of Hematology2006

4. Poster PresentationAmerican Society of Hematology2005

 

 

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